Longevity & Anti-Aging
Humanin
Apoptosis regulator BAX
Mechanism & research context
Mitochondrial-derived peptide studied in neuroprotection and metabolic regulation; early correlational human data.
Safety flags
0 flagsNo curator-recorded safety flags for this entry. Absence of recorded flags is not evidence of safety. Many peptides lack adequate human data.
Research papers
16 recordsCitation links route to PubMed, Europe PMC, and PMC. Presence of a study is not endorsement. Records are refreshed from PubMed on a regular cadence; rows marked “Live search link” will resolve to a current PubMed search until a full citation has been ingested.
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· 2026
Renoprotective Effect of S14G-Humanin on Renal Ischemia/Reperfusion Injury by Activation of STAT3 and ERK 1/2 Signal Transduction Pathways in Rats
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· 2026 Open access
Characterization of the Effects of a Humanin Fragment Peptide (HNF14) in Age-Related Macular Degeneration
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· 2026
Humanin and MOTS-c Attenuate Atrial Fibrillation by Suppressing Fibrosis and Mitochondrial Dysfunction
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· 2026 Open access
Diagnostic potential of serum humanin in breast cancer among the Egyptian population.
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· 2026 Open access
Mitochondria-derived peptides in liver disease: Emerging regulators of hepatic metabolism and therapeutic targets.
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· 2026
Mitochondrial-derived microproteins in lung disease: insights and implications.
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· 2026 Open access
Mitochondrial derived peptide humanin improved semen quality, semen freezability, antioxidant status and in-vitro fertility in crossbred bull.
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· 2026
Diagnostic Value of Serum Humanin-Like 3 Levels in Multiple Sclerosis Patients with Predominant Optic Nerve and Spinal Cord Involvement: A Preliminary Study.
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· 2026
Characterization of the Effects of a Humanin Fragment Peptide (HNF<sub>14</sub>) in Age-Related Macular Degeneration.
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· 2026
Circulating Humanin Improves the Prognostic Accuracy of Cardiovascular Risk Models in Chronic Hemodialysis Patients.
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· 2026
Humanin as an evolutionarily tuned mitochondrial peptide: Insights from mammalian oxidative stress diversity.
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· 2026
[Humanin: a mitochondria-hidden peptide serving inflammation resolution].
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· 2026
Humanin improved the rotenone-induced reactive oxygen species formation in PC12 cells by modulating the SIRT3/Nrf2/HO-1 signaling pathway.
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· 2025 Open access
Exercise Improves Cardiac Dysfunction in D-Galactose-Treated Rats by Regulation of IGF-1-Humanin Pathway.
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· 2025 Open access
Mediterranean diet adherence is associated with mitochondrial microproteins Humanin and SHMOOSE; potential role of the Humanin-Nox2 interaction in cardioprotection.
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Review · PubMed (NCBI) Live search link
PubMed literature search: Humanin
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Clinical trials
7 records-
Live search Live search
Live ClinicalTrials.gov search: Humanin
Condition: See live results
Open on ClinicalTrials.gov ↗ -
NCT03431844 COMPLETED
Prospective Clinical Observational Study of Humanin Isoforms in Cardiac Muscle and Blood Plasma and Their Association to Major Complications After Cardiac Operation
Condition: Myocardial Ischemia; Coronary Artery Bypass Surgery
Sponsor: University of Tartu
Open on ClinicalTrials.gov ↗ -
NCT04104958 UNKNOWN
Identification of Recent Biomarkers in Polycystic Ovary Syndrome Patients as a Predictors of IVF Outcome
Condition: Polycystic Ovary Syndrome
Sponsor: Assiut University
Open on ClinicalTrials.gov ↗ -
NCT05506228 RECRUITING
How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery of Children With Cerebral Palsy and Typically Developed Children (Control).
Condition: Cerebral Palsy; Muscle; Muscle Contracture; Muscle Spasticity
Sponsor: Eva Ponten
Open on ClinicalTrials.gov ↗ -
NCT06105229 UNKNOWN
Clinical Value of Plasma Humanin in Acute Kidney Injury
Condition: Acute Kidney Injury
Sponsor: Guangdong Provincial People's Hospital
Open on ClinicalTrials.gov ↗ -
NCT06125249 UNKNOWN
Humanin's Value for Early Diagnosis and Short-term Prognosis in Patients With AKI After Heart Transplantation
Condition: Acute Kidney Injury; Heart Transplant Surgery
Sponsor: Li zhilian
Open on ClinicalTrials.gov ↗ -
NCT07438002 NA RECRUITING
Effect of Exercise in Patients With Chronic Kidney Disease: TONE Trial
Condition: Chronic Kidney Disease
Sponsor: Casa di Cura Dott. Pederzoli
Open on ClinicalTrials.gov ↗
Doses reported in studies
0 recordsNo study-protocol dose records have been curated for Humanin yet. Absence of records is not evidence of safety — many peptides lack adequate human-trial data in the first place.
Records here are populated from public sources only (ClinicalTrials.gov protocol summaries and FDA-approved labels) and must cite a verifiable source URL. They are not added from forum posts, vendor pages, anecdotal write-ups, or social media.
These entries describe what was studied. They do not tell you what to take, how to reconstitute anything, how to fill a capsule, how often to administer, or where to obtain a compound. If you are considering use of Humanin, those decisions belong with a licensed clinician working from the full label or trial record — not from this summary.
Why this page does not list a dose for self-use
The "Doses reported in studies" section above (when populated) describes what was administered in a cited study or label, under medical supervision, in a specific population. It is not a dosing guide for self-use. Separately, we do not publish anecdotal or community-reported dose ranges, administration methods, vial concentrations, or capsule masses for Humanin. Anecdotal figures for unapproved compounds are not harm-reduction data: they lack denominators for adverse events, cannot account for individual physiology or compound purity, and normalise unsupervised use. See the safety policy for the full reasoning.
If this compound has an FDA-approved label
If a label exists, the regulator-reviewed dosing and administration information is there — read it in the context of a prescriber's evaluation.
Questions worth bringing to a clinician
- What is the evidence for this compound in someone with my history?
- What are the realistic, regulator-reviewed alternatives?
- What would you monitor, and what would make you stop?
If you have already taken a peptide and feel unwell: contact emergency services. In the United States, Poison Control is reachable 24/7 at 1-800-222-1222. Do not wait for a community thread.