Nootropic & Neuropeptides
Dihexa
Also known as: PNB-0408 N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide
Mechanism & research context
Synthetic angiotensin IV analog studied in rodent models of cognitive function. No published human clinical trial data.
Safety flags
0 flagsNo curator-recorded safety flags for this entry. Absence of recorded flags is not evidence of safety. Many peptides lack adequate human data.
Research papers
16 recordsCitation links route to PubMed, Europe PMC, and PMC. Presence of a study is not endorsement. Records are refreshed from PubMed on a regular cadence; rows marked “Live search link” will resolve to a current PubMed search until a full citation has been ingested.
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· 2026 Open access
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
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· 2026 Open access
Temporal proteomic profiling of iPSC-derived human liver organoids reveals optimal maturation for drug metabolism and toxicology.
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· 2025 Open access
The Occurrence of Illicit Smart Drugs or Nootropics in Europe and Australia and Their Associated Dangers: Results from a Market Surveillance Study by 12 Official Medicines Control Laboratories.
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· 2025 Open access
Comparative analysis of small molecule and growth factor-derived human induced pluripotent stem cell-derived hepatocyte-like cells.
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· 2025 Open access
Generation and applications of an expandable and mature hiPSC-derived liver organoid.
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· 2024
Effects of an Angiotensin IV Analog on 3-Nitropropionic Acid-Induced Huntington's Disease-Like Symptoms in Rats.
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· 2024 Open access
Chemical approaches targeting the hurdles of hepatocyte transplantation: mechanisms, applications, and advances.
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· 2024 Open access
Botanical Pesticides: Role of <i>Ricinus communis</i> in Managing <i>Bactrocera zonata</i> (Tephritidae: Diptera).
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· 2022 Open access
Phenotypical, functional and transcriptomic comparison of two modified methods of hepatocyte differentiation from human induced pluripotent stem cells.
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· 2022 Open access
Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy.
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· 2021
Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy
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· 2021 Open access
Robust expansion and functional maturation of human hepatoblasts by chemical strategy.
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· 2021 Open access
Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies.
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· 2021 Open access
AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.
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· 2018
Cognitive benefits of angiotensin IV and angiotensin-(1-7): A systematic review of experimental studies.
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Review · PubMed (NCBI) Live search link
PubMed literature search: Dihexa
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Clinical trials
1 record-
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Live ClinicalTrials.gov search: Dihexa
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Doses reported in studies
0 recordsNo study-protocol dose records have been curated for Dihexa yet. Absence of records is not evidence of safety — many peptides lack adequate human-trial data in the first place.
Records here are populated from public sources only (ClinicalTrials.gov protocol summaries and FDA-approved labels) and must cite a verifiable source URL. They are not added from forum posts, vendor pages, anecdotal write-ups, or social media.
These entries describe what was studied. They do not tell you what to take, how to reconstitute anything, how to fill a capsule, how often to administer, or where to obtain a compound. If you are considering use of Dihexa, those decisions belong with a licensed clinician working from the full label or trial record — not from this summary.
Why this page does not list a dose for self-use
The "Doses reported in studies" section above (when populated) describes what was administered in a cited study or label, under medical supervision, in a specific population. It is not a dosing guide for self-use. Separately, we do not publish anecdotal or community-reported dose ranges, administration methods, vial concentrations, or capsule masses for Dihexa. Anecdotal figures for unapproved compounds are not harm-reduction data: they lack denominators for adverse events, cannot account for individual physiology or compound purity, and normalise unsupervised use. See the safety policy for the full reasoning.
If this compound has an FDA-approved label
If a label exists, the regulator-reviewed dosing and administration information is there — read it in the context of a prescriber's evaluation.
Questions worth bringing to a clinician
- What is the evidence for this compound in someone with my history?
- What are the realistic, regulator-reviewed alternatives?
- What would you monitor, and what would make you stop?
If you have already taken a peptide and feel unwell: contact emergency services. In the United States, Poison Control is reachable 24/7 at 1-800-222-1222. Do not wait for a community thread.